RAD140 is also called Testolone. Many brands and manufacturers market it as the strongest SARM on the market. Is that a true? What research says about RAD140?
So, what is RAD140?
RAD140 is a potent, orally bioavailable, nonsteroidal selective androgen receptor modulator (SARM). Researchers have found that Testolone prevents the production of ESR1 protein, one of the compounds catalyzing breast cancer. It suppresses cancer growth by blocking the effect estrogen may have on surrounding tissue. Testolone also protects brain nerves by blocking amyloid-beta proteins. These proteins are responsible for the development of Alzheimer’s disease. It also increases learning and memory capacity by affecting brain cell growth.
Now you know what is RAD140 but what is Androgen receptor (AR)?
The androgen receptor (AR) is a member of the steroid hormone nuclear receptor superfamily that includes estrogen, progestin, glucocorticoid and mineralocorticoid receptors.1 The binding of the prototypical, endogeneously produced androgen testosterone (1) and the important active metabolite dihydrotestosterone (2) to AR initiates a remarkably diverse array of biological activities that can vary according to a subject’s sex, age and hormonal status. The activity of AR is critical to normal human sexual development and function, but beyond this signature role, AR activation also has important effects on diverse targets such as bone, liver, muscle and the central nervous system.2,3 The therapeutic potential of androgen signaling is well-appreciated in the medicinal chemistry community, and for quite some time, chemists have sought compounds that selectively stimulate muscle and bone growth while minimizing the proliferative and/or hypertrophic effects on sex tissues such as the prostate in males and clitoris in females
History of RAD 140 Testolone
Pharmaceutical company Radius health has developed Testolone in 2010. The main reason for finding this product was not gain in muscle mass but they wanted to cure osteoporosis and breast cancer treatment. It actually suppresses cancer growth by blocking the effect estrogen may have on surrounding tissue.Usually, in the history, scientists were trying to find something new in the specific area, but they found something new in different environment what was not planned. It was same story with RAD 140. In early stages, trials were conducted on monkey and mice. What the researchers found was that Testolone stimulated lean muscle gains without affecting the prostate or raising blood pressure, which is very different to steroids. There was not found increase in transaminase either, which is liver enzyme. Research also shows that these substances prevent brain cell death, providing neuroprotective effects at the same time.
What does it all mean?
SARMs are selective in everything they do. By binding to the androgen receptors in a selective way, you’ll experience benefits without having to worry about side effects. So, they affect certain androgen receptors in order to increase muscle mass, for example. According to studies, RAD140 demonstrated excellent affinity for the androgen receptor Testosterone and DHT.
You can’t really compare Testolone (RAD140) to any other SARMs. It is much more effective than compounds like LGD-4033 and MK-2866. However, this compound still needs to be more researched. Compare to Ostarine, which was tested on humans, RAD140 is pretty new to the scientific research.
Testolone RAD140 is probably the best and the safest selective androgen receptor modulator on the market. Using Testolone, you can expect the same results as the ones you can obtain from a cycle of Dianabol, without all the hideous side effects. This perfectly explains why more people opt for this product over the other aggressive alternatives.
What does RAD140 do?
Almost everyone wants the benefits of taking anabolic steroids, but not everyone is ready to accept the downsides of consuming them. Luckily, Testolone RAD140 is formulated to deliver incredible results without adverse reactions. Athletes have noticed a huge increase in lean muscle mass and strength. There is also possible to lose fat while building muscle mass.
RAD140 has been referred to anabolic: androgenic ratio of 80:1. Compounds with this type of ratio can really increase muscle mass and gain more than 10lbs of muscle in a few weeks.
To put things to perspective:
Testosterone is the main male hormone synthesised in the testis. The hormone is responsible for the secondarysexual characteristics that transform boys into men. In the adult male, testosterone regulates muscle protein metabolism, sexual and cognitive functions, erythropoiesis, plasma lipids, and bone metabolism. Testosterone has approximately equal anabolic and androgenic actions. It is inactive orally because it has a high ﬁrst pass effect.
Testosterone 1:1, RAD140 80:1, some pages claim it is almost 90:1!!
Benefits of RAD 140
1. RAD140 helps increase muscle mass
The number one benefit of supplementing with RAD140 is its ability to increase lean tissue without increasing fat. In fact, during initial studies done on monkeys, scientists observed an average weight gain of more than 10% in just 28 days. This was done using only RAD 140 and without any adverse side effects traditionally related to testosterone.
2. RAD140 may enhance speed, stamina, and endurance during high-intensity workouts
Want to work out longer, harder and get better results every time you hit the gym? Reports of enhanced speed, stamina, and endurance during workouts are common when supplementing with Testolone. Additionally, thanks to its ability to increase lean muscle tissue and decrease fat, high-intensity workouts and interval training can be optimized every time.
3. RAD140 has a greater anabolic effect than testosterone
Similar to other SARMs such as LGD4033 (Ligandrol) or S4 (Andarine), RAD140 produces similar results to testosterone but without the side effects. RAD140 interacts with the hormonal receptors of muscle and bone tissue in the same ways as larger doses of testosterone, all without the estrogenic side effects caused by anabolic steroids. So, it can increase libido and sperm count.
4. Increases your metabolism
If your slow metabolism is interfering with your weight, then RAD-140 is just the one to help you. In addition, it helps reduce fat thanks to the increased rate that your body is working at.
5. Increases vascularity (full pumped look)
You’ll notice this during workouts and outside the gym, but RAD-140 will give you some truly astounding vascularity. The best part, this will stay that way even after you have completed a cycle. Therefore, your gains will be permanent.
The best dosage for cutting and bulking?
There are many opinions about the dosage. Always follow what is on the label. In general, the most effective dosages are between 10mg to 20mg and you should not run RAD140 longer than 8 weeks. As it is very anabolic, PCT is necessary to get your testosterone to normal levels after taking RAD 140.
What is the dosage for cutting?
The research says that sarms were originally found to prevent muscle waisting, therefore almost every sarm is good for cutting. This is beneficial especially when you are on a low calorie diet. You can use a lower dosage of 10-15mg to get the results. Although, if you are an experienced athlete, you can go for 20-25mg. Keep in mind you need to up your protein intake and we also recommend to go higher with carbs and lower with fats, but all depends on your preferences and diet.
What is the dosage for bulking?
The bulking dosage is usually about 20-30mg per day. You should run it for at least 12 weeks. Why are we saying 12 weeks when we said in general it is 8 weeks? Well, there are different opinions. If you take RAD140 casually and do not have strict diet, 8 weeks is more than enough. However, if you are taking bodybuilding seriously and have done some stacks before, 12 weeks is more beneficial. The half life of RAD 140 is 20 hours, so using it once a day is enough or you can split the dosage to 50% in the morning and 50% before training. You should also train with heavy weights to get the most of it. You can also start with lower dosage and gradually increase if you want to start slowly.
Any side effects?
This SARM is considered to be one of the newer SARMs and there isn’t a lot of information on side effects available.
With the information we do have, clinical studies suggest that there are no reported side effects. Not even gyno, hair loss or acne.
When we look at customer experience, RAD140 does not have any major side effects apart from temporary suppression or nausea. This might be also caused by overdosing RAD140 and it is not reliable. Therefore, those compounds need to be researched more in order to make a conclusion. This is the reason why you must use PCT after cycle of Rad 140. It is very important to get your hormone levels back to normal as they can be affected due to high increase in testosterone.
What can you stack with RAD140?
For fat loss stack RAD 140 with Cardarine
Stacking RAD140 and GW-50516, also known as Cardarine, is one of the most powerful stacks. Alongside a strict exercise regimen, it is known to improve stamina and endurance. In this tack, Rad 140 has the role to build lean muscle and prevent muscle waisting. Where Cardarine is better for actual fat-burning effect.
For fast building muscle stack with LGD
RAD140/LGD stack is simply an ANABOLIC super combo. This combination is not for everyone. We do recommend to use this stack if you are an experienced athlete. That is why PCT is super important. This stack will help you go through the plateau but more importantly build muscle mass very quickly. These 2 compounds are very similiar but stacking them together will double the effect.
To execute this stack, it is recommended to do an eight-week long cycle. Use 5mg of Ligandrol once a day, paired with 10mg of Testolone also once a day. They both have a long half-life, so only need to be taken once a day, which is a huge perk. By also keeping the doses relatively low, it also eliminates a lot of the possible side effects associated with combining two powerful SARMs.
You can really make a huge transformation with this stack in 4 weeks time. Make sure you take the picture before and after, so everybody can see the difference. We at Nutrition First always want to know your results and listen to your feedback. Let us know.
Stack with MK677 for bulking
This is probably the most popular stack out there for bulking. There are so many bodybuilders who actually have gone off from steroids to try this safer version. If you have this stack, you will grow. You will get the strength in the gym and you will be able to consume more calories as well. MK677 in this stack works as growth hormone secretagogue, it will boost your HGH which is good for recovery, sleep and of course growing. Rad 140 will increase your test levels. This combination can make you look completely different in 12 weeks time. If you are serious about bodubuilding, this is for you.
There is more stacks that you can consider:
Results to expect from RAD140 before and after
Athletes have reported in average 8lbs of lean muscle gain on 12 week cycle. This is an incredible result what you can expect from RAD 140. Normally, it kicks in in your 2-3rd week, and that is why 4 week cycle is pointless. If you use it on its own, you can also expect fat loss as you will be able to build lean muscle if you keep your diet same as normal, which is great because you do not have to change it at all. So, before taking this compound we recommend you to train at least few months naturally. And then, when you start hitting plateau, you can also start with Rad 140. Remember that after the cycle you will need PCT!
PCT after RAD140 cycle
RAD 140 suppresses testosterone via the lowering of FSH and LH, a consequence of its binding affinity to the AR.
Some RAD 140-users get their testosterone levels checked post-cycle and experience significant suppression, causing them to run a PCT (post cycle therapy).
Users can begin a PCT five days after finishing a RAD 140 cycle, due to its short half life (60 hours), with it lasting for 4 weeks. However, some of the athletes did not report any suppression, we still recommend PCT.
What is the Half Life of RAD 140 (Testolone)?
Based on pharmacokinetic samples, RAD 140’s half life is 60 hours .
However, daily dosing remains a common protocol among users, who initially estimated its half life to be around 20 hours.
RAD 140 vs LGD-4033
LGD-4033 (Ligandrol) is the more potent SARM mg for mg, with dosages of only 2-10mg needed to cause positive changes in body composition. RAD 140’s dosage is typically 10-20mg.
RAD 140 seems to be a superior SARM, in regards to increased pumps and subcutaneous fat loss.
Thus, in terms of aesthetics and looking in the best condition for the beach or a contest — RAD 140 wins. In contrast, LGD-4033 is a bulkier compound that won’t leave users looking ripped.
Some of the fat loss associated with RAD 140 may be indirect, due to it having a more appetite suppressant effect compared to LGD-4033.
In terms of muscle hypertrophy and strength — LGD-4033 wins, making it a more optimal compound for bulking.
RAD 140 has a greater muscle hardening effect, possibly due to estrogen levels rising less, and thus decreasing water retention.
RAD 140 is also likely to produce better results in terms of muscular endurance, benefiting those who perform in high rep ranges, or have a training schedule that incorporates regular cardiovascular training.
Many users also report higher energy levels on RAD 140, than LGD-4033.
LGD-4033 however is known to increase libido more so than RAD 140 on-cycle.
How does RAD140 compares to other SARMs?
The RAD-140 Testolone aims at permanent muscle gains and a uniform body shape.
Compared to other SARMs, the profits – according to user testimonials – are clearly more stable, more consistent and greater.
The loss of body fat becomes apparent within the first weeks of use, a fact that is also assisted by the effective muscle reconstruction achieved on the body.
Which RAD140 do you recommend?
Any of our RAD140 can be used. The price is usually different as brands price it differently. However, there is no difference between them. Some of them might have higher mg per serving. So, always double check servings.
RAD140 is a very powerful SARM that still needs a lot of research. Customers say it is the best SARM out there and compare it to anabolic steroids. If you aim to increase your bodyweight fast, this is for you but do not forget on PCT. When you buy RAD140, always research the brand and customer’s feedback. There are a lot of SARMs on the market that do not contain what is on the label.
Nutrition First only provide the best quality supplements that our customers love.
Sources used: ACS Med Chem Lett research
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