RAD140 is also called Testolone. Many brands and manufacturers market it as the strongest SARM on the market. Is that a true? What research says about RAD140?
So, what is RAD140?
RAD140 is a potent, orally bioavailable, nonsteroidal selective androgen receptor modulator (SARM). Researchers have found that Testolone prevents the production of ESR1 protein, one of the compounds catalyzing breast cancer. It suppresses cancer growth by blocking the effect estrogen may have on surrounding tissue. Testolone also protects brain nerves by blocking amyloid-beta proteins. These proteins are responsible for the development of Alzheimer’s disease. It also increases learning and memory capacity by affecting brain cell growth.
Now you know what is RAD140 but what is Androgen receptor (AR)?
The androgen receptor (AR) is a member of the steroid hormone nuclear receptor superfamily that includes estrogen, progestin, glucocorticoid and mineralocorticoid receptors.1 The binding of the prototypical, endogeneously produced androgen testosterone (1) and the important active metabolite dihydrotestosterone (2) to AR initiates a remarkably diverse array of biological activities that can vary according to a subject’s sex, age and hormonal status. The activity of AR is critical to normal human sexual development and function, but beyond this signature role, AR activation also has important effects on diverse targets such as bone, liver, muscle and the central nervous system.2,3 The therapeutic potential of androgen signaling is well-appreciated in the medicinal chemistry community, and for quite some time, chemists have sought compounds that selectively stimulate muscle and bone growth while minimizing the proliferative and/or hypertrophic effects on sex tissues such as the prostate in males and clitoris in females
History of RAD 140 Testolone
Pharmaceutical company Radius health has developed Testolone in 2010. The main reason for finding this product was not gain in muscle mass but they wanted to cure osteoporosis and breast cancer treatment. It actually suppresses cancer growth by blocking the effect estrogen may have on surrounding tissue.Usually, in the history, scientists were trying to find something new in the specific area, but they found something new in different environment what was not planned. It was same story with RAD 140. In early stages, trials were conducted on monkey and mice. What the researchers found was that Testolone stimulated lean muscle gains without affecting the prostate or raising blood pressure, which is very different to steroids. There was not found increase in transaminase either, which is liver enzyme. Research also shows that these substances prevent brain cell death, providing neuroprotective effects at the same time.
What does it all mean?
SARMs are selective in everything they do. By binding to the androgen receptors in a selective way, you’ll experience benefits without having to worry about side effects. So, they affect certain androgen receptors in order to increase mus