5-Amino-1MQ 10mg Lyophilized Powder (NNMT Inhibitor)

Unlock new insights into cellular metabolism with our premium 5-Amino-1MQ 10mg vials. This highly purified small molecule serves as a premier tool for researchers investigating nicotinamide metabolism, enzyme regulation, and cellular energetics. Engineered to meet strict laboratory standards, each vial provides a reliable, stable format for assessing Nicotinamide N-Methyltransferase (NNMT) pathways and intracellular dynamics.

- Product Form: High-purity lyophilised powder
- Total Content: 10mg per sterile glass vial
- Target Mechanism: Potent NNMT enzyme inhibitor
- Storage Requirements: Keep frozen at -20°C for optimal shelf life

Mechanism of Action & Molecular Pathways

5-Amino-1MQ is primarily investigated for its targeted intervention in the body’s baseline metabolic machinery. In biochemical models, it acts as a selective blocker of the NNMT enzyme. This specific pathway is highly significant because NNMT converts nicotinamide into methylated compounds, directly competing with the vital NAD+ salvage pathway.

When researchers introduce 5-Amino-1MQ into a cellular model, they typically monitor:

- NAD+ Bioavailability: Tracking shifts in intracellular NAD+ levels and recycling efficiency.
- Mitochondrial Activity: Observing changes in baseline cellular energy production and ATP synthesis.
- Metabolic Homeostasis: Evaluating how cells adapt their energy expenditures when NNMT is suppressed.

Primary Research Applications

This compound is widely utilized across molecular biology and metabolic disease research framework models. Investigators leverage 5-Amino-1MQ to observe systemic responses to altered enzyme activity.

- Adipose Tissue Regulation: Extensively featured in diet-induced obesity and metabolic syndrome models to observe how fat tissue responds to lowered NNMT activity.
- Enzyme Kinetics: Ideal for mapping the specific downstream effects of nicotinamide methylation.
- Cellular Respiration: Utilised to evaluate alternative cellular pathways when standard salvage cycles are disrupted.

Technical Specifications & Chemical Profile

Property	Specification
Chemical Identification	5-Amino-1MQ
Molecular Formula	C₇H₁₀N₂O
Molecular Weight	138.17 g/mol
Physical Appearance	White to off-white pristine powder
Vial Architecture	Securely sealed, sterile glass container
Solubility Profile	Readily soluble in standard laboratory organic solvents (e.g., DMSO)

Handling, Stability, and Safety Constraints

To guarantee consistent assay results, this compound requires strict adherence to laboratory storage protocols. The powder should be kept continuously at -20°C. Avoid repeated freeze-thaw cycles after reconstitution to preserve molecular integrity.

Because 5-Amino-1MQ operates deep within fundamental cellular pathways, research profiles regarding its broader physiological limitations remain an ongoing area of study. Outcomes fluctuate depending on the specific cell line or animal model deployed.

Laboratory Research Disclaimer: This product is manufactured and distributed exclusively for in vitro and in vivo laboratory research purposes. It is strictly not intended for diagnostic, therapeutic, medical, or human consumption.